An efficient Passerini tetrazole reaction (PT-3CR)?
Green Chemistry Pub Date: 2016-05-19 DOI: 10.1039/C6GC00910G
Abstract
A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed. It comprises the reaction of an aldehyde/ketone, an isocyanide and a TMS-azide in methanol?:?water (1?:?1) as the solvent system. The use of sonication not only accelerated the rate of the reaction but also provided good to excellent quantitative yields. This reaction is applicable to a broad scope of aldehydes/ketones and isocyanides.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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