An efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction?
Organic Chemistry Frontiers Pub Date: 2019-04-18 DOI: 10.1039/C9QO00380K
Abstract
An efficient protocol for the synthesis of 1,1,2-triarylethanes and 2,2-diarylethylamine with biological and pharmacological potential via organo-photoredox-catalyzed decarboxylative 1,6-conjugate addition of carboxylic acids to para-quinone methides has been developed. Different from the traditional transition-metal catalyzed multi-step synthetic strategy, our process involves a photoredox-promoted free radical pathway. A variety of structurally diverse products can be easily obtained under metal-free conditions in good to excellent yields (38 examples, up to 98% yield) in one step.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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