Application of a 2-aryl indenylphosphine ligand in the Buchwald–Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions?
Organic & Biomolecular Chemistry Pub Date: 2017-06-19 DOI: 10.1039/C7OB01199G
Abstract
An efficient solvent-free protocol for the Buchwald–Hartwig cross-coupling reaction of aryl and heteroaryl chlorides with primary and secondary amines using the Pd(dba)2/ligand 1 catalytic system has been developed. Notably, the catalytic system also efficiently catalyzed the reaction under aqueous conditions.
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Journal Name:Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4