Anti-Markovnikov hydroimination of terminal alkynes in gold-catalyzed pyridine construction from ammonia?

Chemical Communications Pub Date: 2015-06-24 DOI: 10.1039/C5CC04091D

Abstract

Gold-catalyzed hydroimination of terminal alkynes, giving rise to anti-Markovnikov adducts concomitant with unstable Markovnikov adducts is described. The elementary step can be applied for the construction of pyridine derivatives from ammonia and alkynes.

Graphical abstract: Anti-Markovnikov hydroimination of terminal alkynes in gold-catalyzed pyridine construction from ammonia
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