Application of combined photobiomodulation and curcumin-loaded iron oxide nanoparticles considerably enhanced repair in an infected, delayed-repair wound model in diabetic rats compared to either treatment alone

Photochemical & Photobiological Sciences Pub Date: 2023-04-11 DOI: 10.1007/s43630-023-00411-7

Abstract
Herein, we attempted to?evaluate the therapeutic potential of photobiomodulation (PBM) and curcumin-loaded iron nanoparticles (CUR), alone and in combination, on wound closure rate (WCR), microbial flora by measuring colony-forming units (CFUs), the stereological and biomechanical properties of repairing wounds in the maturation stage of the wound healing course in an ischemic infected delayed healing wound model (IIDHWM) of type I diabetic (TIDM) rats. There were four groups: group 1 was the control, group 2 received CUR, rats in group 3 were exposed to PBM (80?Hz, 890?nm, and 0.2?J/cm2), and rats in group 4 received both PBM and CUR (PBM?+?CUR). We found CFU was decreased in groups 2, 3, and 4 compared to group 1 (p?=?0.000 for all). Groups 2, 3, and 4 showed a considerable escalation in WCR compared to group 1 (p?=?0.000 for all). In terms of wound strength parameters, substantial increases in bending stiffness and high-stress load were observed in groups 2, 3, and 4 compared to group 1 (p?=?0.000 for all). Stereological examinations revealed decreases in neutrophil and macrophage counts and increases in fibroblast counts in groups 2, 3, and 4compared to group 1 (p?=?0.000 for all). Blood vessel counts were more dominant in the PBM and PBM?+?CUR?groups over group 1 (p?=?0.000 for all). CFU and wound strength as well as macrophage, neutrophil, and fibroblast counts were found to be improved in the PBM?+?CUR and PBM?groups compared to the CUR group (ranging from?p?=?0.000 to?p? View Original Text
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