Alkynylation of steroids via Pd-free Sonogashira coupling?
Organic & Biomolecular Chemistry Pub Date: 2015-04-08 DOI: 10.1039/C5OB00559K
Abstract
Cu-catalyzed Pd-free Sonogashira coupling has been proposed as a straightforward and convenient route to valuable steroidal enynes. A biligand catalyst system based on Ph3P and TMEDA has been designed. The protocol was utilized for the efficient coupling of iodosteroids with diverse terminal alkynes and 1-trimethylsilylalkynes. A possible role of an auxiliary ligand as a phase-transfer catalyst for a sparingly soluble inorganic base (K2CO3) was revealed.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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