Aldol reactions mediated by a tetrahedral boronate?

Chemical Communications Pub Date: 2012-11-16 DOI: 10.1039/C2CC37047F

Abstract

The base is a key factor in aldol reactions in organic media, determining the selectivity. Here, we describe a tetrahedral phenylboronate salt as a mild non-nucleophilic base that is able to catalyse the aldol reaction and significantly decrease the formation of undesired elimination products.

Graphical abstract: Aldol reactions mediated by a tetrahedral boronate
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