5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of π-extended heteroarylfuran systems?

Organic & Biomolecular Chemistry Pub Date: 2003-04-04 DOI: 10.1039/B302767H

Abstract

5-Formyl-2-furylboronic acid reacts cleanly with a range of heteroaryl bromides under Suzuki–Miyaura cross-coupling conditions to produce 2-formyl-5-heteroarylfuran derivatives. Subsequent Wittig olefination reactions afford π-conjugated alkenepyridylfuran derivatives.

Graphical abstract: 5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of π-extended heteroarylfuran systems
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