An organic solvent free process for the demethylation of 4-(4-methoxyphenyl)butanoic acid
Green Chemistry Pub Date: 2005-12-08 DOI: 10.1039/B512176K
Abstract
A mild and efficient organic solvent free process has been developed for the synthesis of 4-(4-hydroxyphenyl)butanoic acid, a key intermediate in the synthesis of LY518674. Thus we have achieved the demethylation of 4-(4-methoxyphenyl)butanoic acid with only a slight excess of aqueous HBr and without phase transfer catalysis. In addition, 4-(4-hydroxyphenyl)butanoic acid is easily obtained by direct crystallization from the reaction mixture.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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