Visible-light-induced tandem radical addition/cyclization of 2-alkenylphenols and CBr4 for the synthesis of 4-arylcoumarins?
Organic Chemistry Frontiers Pub Date: 2021-07-07 DOI: 10.1039/D1QO00831E
Abstract
A visible-light-induced photoredox-catalyzed tandem radical addition/cyclization of 2-alkenylphenols and CBr4 is developed. This protocol features mild and redox-neutral reaction conditions, good functional group tolerance, and operational simplicity, providing efficient and practical access to various 4-arylcoumarins in a one-pot fashion. Preliminary mechanistic investigations confirm a radical process and the significant role of the additive water.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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