Transition-metal free 2-arylbenzoxazole formation from aryl amides and cyclohexanones?
Green Chemistry Pub Date: 2014-08-28 DOI: 10.1039/C4GC01572J
Abstract
A transition-metal-free method for the synthesis of 2-arylbenzoxazoles from readily available cyclohexanones and benzamides is described. The combined use of KI, p-TsOH and DMSO significantly improved the reaction yields. Non-aromatic cyclohexanones were smoothly dehydrogenated and acted as the aryl source using oxygen as the oxidant.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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