Total synthesis of dendrobate alkaloid (+)-241D, isosolenopsin and isosolenopsin A: application of a gold-catalyzed cyclization?
Organic & Biomolecular Chemistry Pub Date: 2012-06-01 DOI: 10.1039/C2OB25685A
Abstract
A new approach to total syntheses of piperidine alkaloids (+)-241D, isosolenopsin and isosolenopsin A has been developed from D-alanine. The key step to access the chiral pyridinone intermediate was achieved via a gold mediated cyclization. Finally, various reduction conditions afforded the natural products in few steps and good overall yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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