The verticillenes. Pivotal intermediates in the biosynthesis of the taxanes and the phomactins
Natural Product Reports Pub Date: 2018-07-06 DOI: 10.1039/C8NP00034D
Abstract
Covering: up to May 2018
The verticillene family of 6,12-membered ring-fused diterpenes are found in plants, liverworts, corals and insects. Carbocations derived from verticillene hydrocarbons are central intermediates in the biosynthesis of the taxane and the phomactin families of polycyclic natural products. This perspective delineates these unique biosynthetic interrelationships, which are reinforced by recent biomimetic synthesis investigations, alongside quantum chemical calculations and targeted engineering studies of the taxadiene synthase (TXS) cascade.
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Journal Name：Natural Product Reports
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CAS no.: 89640-58-4
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