The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach

Chemical Communications Pub Date: 2011-11-09 DOI: 10.1039/C1CC16173C

Abstract

While the use of additives to control the crystallization of polymorphs is well known, similar methodology to promote the crystallization of a metastable conglomerate over a stable racemic compound in enantiomeric systems has not been reported. Here we demonstrate this phenomenon in the case of 2-chloromandelic acid.

Graphical abstract: The isolation of a metastable conglomerate using a combined computational and controlled crystallization approach
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