The chemistry and biology of guanidine secondary metabolites

Natural Product Reports Pub Date: 2020-10-06 DOI: 10.1039/D0NP00051E

Abstract

Covering: 2017–2019

Guanidine natural products isolated from microorganisms, marine invertebrates and terrestrial plants, amphibians and spiders, represented by non-ribosomal peptides, guanidine-bearing polyketides, alkaloids, terpenoids and shikimic acid derived, are the subject of this review. The topics include the discovery of new metabolites, total synthesis of natural guanidine compounds, biological activity and mechanism-of-action, biosynthesis and ecological functions.

Graphical abstract: The chemistry and biology of guanidine secondary metabolites
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