Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids?
RSC Advances Pub Date: 2015-04-07 DOI: 10.1039/C5RA00584A
Abstract
A new series of imidazo[1,2-a]pyrazine–coumarin hybrids have been synthesized by the combination of two biologically active moieties, imidazo[1,2-a]pyrazine and coumarin, followed by the Suzuki–Miyaura cross coupling reaction for monoarylation at the C6 position and symmetrical/unsymmetrical diarylation at the C3 and C6 positions. These compounds were further screened for their in vitro antitumor activities.
![Graphical abstract: Synthesis, in vitro anticancer activity and SAR studies of arylated imidazo[1,2-a]pyrazine–coumarin hybrids](http://scimg.chem960.com/usr/1/C5RA00584A.jpg)
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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