Synthesis of chiral cyclic amines via Ir-catalyzed enantioselective hydrogenation of cyclic imines?
Organic & Biomolecular Chemistry Pub Date: 2017-03-08 DOI: 10.1039/C7OB00442G
Abstract
A highly enantioselective hydrogenation of cyclic imines for synthesis of chiral cyclic amines has been realized. With the complex of iridium and (R,R)-f-spiroPhos as the catalyst, a range of cyclic 2-aryl imines were smoothly hydrogenated under mild conditions without any additive to provide the corresponding chiral cyclic amines with excellent enantioselectivities of up to 98% ee. Moreover, this method could be successfully applied to the synthesis of (+)-(6S,10bR)-McN-4612-Z.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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