Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride?
Chemical Science Pub Date: 2019-01-29 DOI: 10.1039/C8SC05096A
Abstract
Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation.
![Graphical abstract: Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride](http://scimg.chem960.com/usr/1/C8SC05096A.jpg)
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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