Synthesis and characterization of various 5′-dye-labeled ribonucleosides?

Organic & Biomolecular Chemistry Pub Date: 2018-08-21 DOI: 10.1039/C8OB01606B

Abstract

Hitherto unknown chromophoric nucleosides are reported. This novel set of visibly coloured dye-labeled 5′-nucleosides, including 1,2,4,5-tetrazine, dicyanomethylene-4H-pyran, benzophenoxazinone, 9,10-anthraquinone and azobenzene chromophores, were prepared mainly under Cu-catalyzed azide–alkyne cycloaddition (CuAAC). The design criteria are outlined. Several derivatives possess in supplement a fluorescence property. The absorption and fluorescence spectra of all coloured nucleosides were recorded to study their potential as visible-range probes. Such nucleodyes are of great interest for future competitive lateral flow test MIP-based strips.

Graphical abstract: Synthesis and characterization of various 5′-dye-labeled ribonucleosides
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