Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides??

Chemical Communications Pub Date: 2011-11-14 DOI: 10.1039/C1CC15990A

Abstract

A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)2 and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products. Surprisingly, a dramatic temperature dependence in product selectivity was observed.

Graphical abstract: Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides
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