Structure-guided stereoselectivity inversion of a short-chain dehydrogenase/reductase towards halogenated acetophenones?
Chemical Communications Pub Date: 2016-04-11 DOI: 10.1039/C6CC00051G
Abstract
The structure-guided rational design of an NADH-dependent short-chain dehydrogenase/reductase (SDR) reversed the stereoselectivity towards halogenated acetophenones from Prelog to anti-Prelog. The enzyme–substrate interactions involving an aromatic ring and a halogen atom were proven to play critical roles in determining the stereoselectivity of these ketone reductions besides the steric repulsion.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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