Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization?
RSC Advances Pub Date: 2022-01-07 DOI: 10.1039/D1RA07944A
Abstract
A green, simple and efficient method is developed for the synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization of 2-aminobenzamides and aldehydes under visible light irradiation. The reaction proceeds using fluorescein as a photocatalyst in the presence of TBHP without the need for a metal catalyst. In addition, this reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields. Thus, the present synthetic method provides a straightforward strategy for the synthesis of quinazolin-4(3H)-ones.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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