Storable palladacycles for selective functionalization of alkyne-containing proteins??

Chemical Communications Pub Date: 2013-06-03 DOI: 10.1039/C3CC43479F

Abstract

We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

Graphical abstract: Storable palladacycles for selective functionalization of alkyne-containing proteins
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