Stereospecific radiosynthesis of 3-fluoro amino acids: access to enantiomerically pure radioligands for positron emission tomography?
Organic & Biomolecular Chemistry Pub Date: 2018-03-15 DOI: 10.1039/C8OB00184G
Abstract
A variety of substituted non-racemic aziridine-2-carboxylates equivalent to amino acids were prepared and subjected to ring opening reaction by [18F/19F]fluoride. The regio and stereospecific ring opening depends on the substituents on the nitrogen as well as both the carbons of aziridines. The applicability of the methods to afford access to 3-[18F/19F]fluoro amino acids are illustrated.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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