Stereoselective functionalization of platensimycin and platencin by sulfa-Michael/aldol reactions?
Organic & Biomolecular Chemistry Pub Date: 2019-02-21 DOI: 10.1039/C9OB00324J
Abstract
Bioinspired sulfa-Michael/aldol cascade reactions have been developed for the semisynthesis of sulfur-containing heterocyclic derivatives of platensimycin and platencin, with three newly formed contiguous stereogenic centers. Density functional theory calculations revealed the mechanism for the stereochemistry control. This method was used in a synthesis of a platensimycin thiophene analogue with potent antibacterial activities against Staphylococcus aureus.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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