Rapid carbonylative coupling reactions using palladium(i) dimers: applications to 11CO-radiolabelling for the synthesis of PET tracers?

Organic & Biomolecular Chemistry Pub Date: 2011-02-25 DOI: 10.1039/C1OB05268C

Abstract

Palladium dimers with sterically hindered phosphines have been shown to be excellent pre-catalysts for the aminocarbonylation of aryl halides to yield amides and one of them has been successfully employed as a pre-catalyst for the synthesis of 11C-radiolabelled amides for PET imaging.

Graphical abstract: Rapid carbonylative coupling reactions using palladium(i) dimers: applications to 11CO-radiolabelling for the synthesis of PET tracers
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