Preparation and reactions of polyfunctional magnesium and zinc organometallics in organic synthesis?
Chemical Science Pub Date: 2021-03-16 DOI: 10.1039/D1SC00685A
Abstract
Polyfunctional organometallics of magnesium and zinc are readily prepared from organic halides via a direct metal insertion in the presence of LiCl or a Br/Mg-exchange using iPrMgCl·LiCl (turbo-Grignard) or related reagents. Alternatively, such functionalized organometallics are prepared by metalations with TMP-bases (TMP = 2,2,6,6-tetramethylpiperidyl). The scope of these methods is described as well as applications in new Co- or Fe-catalyzed cross-couplings or aminations. It is shown that the use of a continous flow set-up considerably expands the field of applications of these methods and further allows the preparation of highly reactive organosodium reagents.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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