Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+?

Chemical Communications Pub Date: 2017-04-05 DOI: 10.1039/C7CC02056B

Abstract

A new photocleavable analog of BAPTA chelating ligand has a high affinity towards Ca2+ ions (K = 2.5 × 106 M?1). The use of photolabile 3-(hydroxymethyl)-2-naphthol core in the design of photo-BAPTA allows for the efficient (Φ = 0. 63) and very fast (τ < 12 μs) release of Ca2+ ions upon 300 or 350 nm irradiation.

Graphical abstract: Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+
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