Phosphine-catalyzed domino reaction: a novel sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives?

Chemical Communications Pub Date: 2013-11-15 DOI: 10.1039/C3CC47716A

Abstract

We have successfully developed a novel and efficient phosphine-catalyzed sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives. The protocol uses readily available γ-substituent allenoates as the starting materials, inexpensive PBu3 as the catalyst, and the corresponding products were obtained in good to excellent yields under mild conditions.

Graphical abstract: Phosphine-catalyzed domino reaction: a novel sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives
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