Pd-Catalyzed double N-arylation of primary amines to synthesize phenoxazines and phenothiazines?

Organic & Biomolecular Chemistry Pub Date: 2017-07-07 DOI: 10.1039/C7OB01540B

Abstract

An efficient and versatile Pd-catalyzed tandem C–N bond formation between aryl halides and primary amines is developed. The transformation allows a one-pot synthesis of phenoxazine and phenothiazine derivatives with a broad range of substitution patterns from readily available precursors.

Graphical abstract: Pd-Catalyzed double N-arylation of primary amines to synthesize phenoxazines and phenothiazines
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