Palladium-catalyzed oxidative direct C–H/C–H cross coupling of anilides with β-keto esters?

Chemical Communications Pub Date: 2013-07-16 DOI: 10.1039/C3CC44769C

Abstract

A Pd(II)-catalyzed oxidative direct C(sp2)–H/C(sp3)–H cross coupling of anilides with α-dicarbonyl compounds with Mn(OAc)3·2H2O as the oxidant is reported and this protocol provides facile access to α-aryl malonates and β-keto esters in good yields and regioselectivity.

Graphical abstract: Palladium-catalyzed oxidative direct C–H/C–H cross coupling of anilides with β-keto esters
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