Palladium catalyzed synthesis of highly substituted naphthalenes via direct ring construction from amides with alkynes?

Chemical Communications Pub Date: 2010-08-23 DOI: 10.1039/C0CC01448F

Abstract

The direct ring construction of amides with alkynes catalyzed by palladium acetate with cheap oxidant under an air atmosphere has been realized. A variety of novel highly substituted naphthalenes 3a–3l have been prepared chemo- and regioselectively in 55–97% yields under mild conditions. Product 3j emits intense blue luminescence peaked at 435 nm with a good blue purity.

Graphical abstract: Palladium catalyzed synthesis of highly substituted naphthalenes via direct ring construction from amides with alkynes
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