Organocatalyzed cascade reactions of carbohydrates – a direct access to C-glycosides?

Chemical Communications Pub Date: 2013-11-13 DOI: 10.1039/C3CC48120D

Abstract

An organocatalyzed transformation to elongate unprotected carbohydrates is described. This operationally simple methodology is based on a Knoevenagel–oxa-Michael cascade. This reaction is catalyzed by proline and DBU. Products were obtained with exceptional high degrees of stereoselectivity.

Graphical abstract: Organocatalyzed cascade reactions of carbohydrates – a direct access to C-glycosides
Recommended Literature