Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach?
Chemical Communications Pub Date: 2014-07-24 DOI: 10.1039/C4CC04852K
Abstract
We discovered a novel organocatalysed multicomponent domino Knoevenagel-aza-Michael-cyclocondensation reaction leading to an unprecedented straightforward synthesis of 1,5-diazabicyclo[3.3.0]octane-2,6-diones. The specific capability of the (DHQ)2PHAL organocatalyst in this process was also highlighted to eventually furnish the corresponding bicyclopyrazolidinones with up to 96?:?4 er.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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