One-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical space?

Organic & Biomolecular Chemistry Pub Date: 2020-09-23 DOI: 10.1039/D0OB01715A

Abstract

As a means to make new benzofuran-embedded polycyclic structures, we established two efficient one-pot sequential coupling routes to 2-amino-3-arylbenzofurans and 2-amino-3-arylnaphtho[2,1-b]furans. Further ring formation (six- and seven-membered rings) with the resulting amine moiety at the C2 position of benzofurans was realized, leading to further expansion of benzofuran-based chemical space.

Graphical abstract: One-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical space
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