Microwave accelerated facile synthesis of fused polynuclear hydrocarbons in dry media by intramolecular Friedel–Crafts alkylation

Organic & Biomolecular Chemistry Pub Date: 2004-01-21 DOI: 10.1039/B311750M

Abstract

Fused polynuclear tetrahydro arenes are synthesised in a fast, simple, high yielding and regiospecific procedure by an intramolecular Friedel–Crafts alkylation in dry media under microwave irradiation of the corresponding 1-bromo-4-arylbutanes immobilised on silica. The observed reactivity is rationalised by molecular modelling studies which suggest the occurence of a concerted mechanism.

Graphical abstract: Microwave accelerated facile synthesis of fused polynuclear hydrocarbons in dry media by intramolecular Friedel–Crafts alkylation
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