An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds?

Chemical Communications Pub Date: 2020-05-11 DOI: 10.1039/D0CC02728F

Abstract

Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.

Graphical abstract: An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
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