Metal-free oxidative direct C(sp3)–H bond functionalization of ethers with α,α-diaryl allylic alcohols?
Chemical Communications Pub Date: 2014-06-27 DOI: 10.1039/C4CC04282D
Abstract
A metal-free method for direct C(sp3)–H bond functionalization of simple ethers with α,α-diaryl allylic alcohols is described. The established protocol provides facile access to α-aryl-β-oxyalkylated carbonyl ketones via radical addition and a 1,2-aryl migration cascade process. An application of the product has been demonstrated in the synthesis of a serotonin antagonist.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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