An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media?

Green Chemistry Pub Date: 2011-10-17 DOI: 10.1039/C1GC15868F

Abstract

A new and environmentally friendly Fmoc protection of a variety of aliphatic and aromatic amines, amino acids, amino alcohols and amino phenols is reported in aqueous media under mild and catalyst-free conditions. The reaction proved to be chemoselective in presence of ambident nucleophiles.

Graphical abstract: An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media
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