Hydroxyapatite-supported Cu(i)-catalysed cyanation of styrenyl bromides with K4[Fe(CN)6]: an easy access to cinnamonitriles?

Organic & Biomolecular Chemistry Pub Date: 2011-10-25 DOI: 10.1039/C1OB06467C

Abstract

An efficient cyanation of styrenyl bromides by K4[Fe(CN)6] has been achieved under the catalysis of hydroxyapatite-supported copper(I) producing a variety of functionalized cinnamonitriles in high yields. The stereochemistry of the styrenyl double bond is preserved during the process providing the same stereoisomer of product.

Graphical abstract: Hydroxyapatite-supported Cu(i)-catalysed cyanation of styrenyl bromides with K4[Fe(CN)6]: an easy access to cinnamonitriles
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