Highly stereoselective synthesis of (?)-monatin, a high-intensity sweetener, using chelation-controlled nitrone cycloaddition?

Chemical Communications Pub Date: 2003-09-24 DOI: 10.1039/B306791M

Abstract

Synthesis of (?)-monatin was achieved by chelation-controlled cycloaddition of nitrone 2 with allyl alcohol 3a in the presence of MgBr2·OEt2.

Graphical abstract: Highly stereoselective synthesis of (?)-monatin, a high-intensity sweetener, using chelation-controlled nitrone cycloaddition
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