An isocyanide insertion approach to substituted pyrrolo[2,3-b]quinolines under metal-free and azide-free conditions?
Organic Chemistry Frontiers Pub Date: 2016-08-08 DOI: 10.1039/C6QO00373G
Abstract
A new strategy for the catalytic synthesis of the pyrrolo[2,3-b]quinoline skeleton by the reaction of isocyanides with (cyclopropylidene(aryl)methyl)aniline (amino-MCPs) is presented, taking advantage of I2/CHP mediated carbodiimide intermediate generation. This reaction involves three C–N bonds and one C–C bond generation under metal-free and azide-free conditions.
![Graphical abstract: An isocyanide insertion approach to substituted pyrrolo[2,3-b]quinolines under metal-free and azide-free conditions](http://scimg.chem960.com/usr/1/C6QO00373G.jpg)
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Journal Name：Organic Chemistry Frontiers
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