Glycal approach to the synthesis of macrolide (?)-A26771B?
RSC Advances Pub Date: 2015-03-16 DOI: 10.1039/C4RA17084A
Abstract
A convergent total synthesis of a 16-membered macrolactone natural product (?)-A26771B 1 starting from 3,4,6-tri-O-acetyl-D-glucal 7 is reported. The Ferrier rearrangement of acetylated glucal 7, cross metathesis between chiral fragments 3 and 4, Yamaguchi macrolactonization and selective oxidation of the allylic alcohol are the key features of the synthesis.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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