From structure to crystallisation and pharmaceutical manufacturing: the CSD in CMAC workflows??
CrystEngComm Pub Date: 2020-09-22 DOI: 10.1039/D0CE00898B
Abstract
Two workflows are presented that are relevant to the design and construction of end-to-end pharmaceutical manufacturing processes. The workflows target the very early stage crystallisation aspect of these processes – production of the primary crystalline solid form – and relate to establishing decision-driven approaches for the screening for multi-component forms, specifically co-crystals, and to the use of additives to control crystal and primary particle form, notably morphology. These workflows are shown to benefit from the use of the million-plus structures in the Cambridge structural database and the associated structural informatics and analysis tools and are placed into the context of the work of the CMAC Future Manufacturing Hub.
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Journal Name：CrystEngComm
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CAS no.: 89640-58-4
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