Formal synthesis of a disaccharide repeating unit (IdoA–GlcN) of heparin and heparan sulfate?
RSC Advances Pub Date: 2015-01-28 DOI: 10.1039/C4RA17050D
Abstract
A concise route to access the key disaccharide repeating unit (IdoA–GlcN) of heparan sulfate is described. The synthesis was accomplished by commercially available diacetone α-D-glucose to functional group transformations, which led to the formation of a L-iduronate donor. This L-iduronate donor was subsequently coupled with a glucosyl acceptor to form the corresponding key disaccharide repeating unit (IdoA–GlcN) of heparan sulfate in good overall yield.
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Journal Name：RSC Advances
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