Electrocatalytic three-component annulation-halosulfonylation of 1,6-enynes toward 1-indanones using sodium halides as both halogen sources and electrolytes?

Green Chemistry Pub Date: 2020-05-25 DOI: 10.1039/D0GC00771D

Abstract

A new electrochemically induced three-component annulation-halosulfonylation of 1,6-enynes has been developed for stereoselective synthesis of 33 examples of 1-indanones with generally good yields under environmentally benign conditions. This electrochemical strategy can proceed in a simple undivided cell, avoiding any transition metal catalysts, chemical oxidants and additives. This reaction tolerates a wide scope of substrates, which provides a new and green access to fabricate important bioactive 1-indanone scaffolds. Notably, readily available and low-cost halogen salts play triple roles of an electrolyte and a redox catalyst as well as a halogenating reagent.

Graphical abstract: Electrocatalytic three-component annulation-halosulfonylation of 1,6-enynes toward 1-indanones using sodium halides as both halogen sources and electrolytes
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