Efficient synthesis of pyrrolo[1,2-a]quinoxalines catalyzed by a Br?nsted acid through cleavage of C–C bonds?
Organic & Biomolecular Chemistry Pub Date: 2016-08-10 DOI: 10.1039/C6OB01401A
Abstract
An efficient and convenient one-pot domino reaction for the direct synthesis of pyrrolo[1,2-a]quinoxalines has been developed. This approach utilizes an imine formation reaction, SEAr reaction and cleavage of C–C bonds catalyzed by a Br?nsted acid. β-Diketones and β-keto esters are both well tolerated to give the corresponding products in moderate to excellent yields.
![Graphical abstract: Efficient synthesis of pyrrolo[1,2-a]quinoxalines catalyzed by a Br?nsted acid through cleavage of C–C bonds](http://scimg.chem960.com/usr/1/C6OB01401A.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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