Access to novel imidazo[1,5-a]pyrazine scaffolds by the combined use of a three-component reaction and a base-assisted intramolecular cyclization?
Organic & Biomolecular Chemistry Pub Date: 2014-05-22 DOI: 10.1039/C4OB00676C
Abstract
A novel and practical two-step approach to an intriguing class of imidazo[1,5-a]pyrazines with exocyclic C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
X (X = CH2, O) bonds is described. The process utilizes a sequential three-component reaction of propargyl amine or aminoester, 1,2-diaza-1,3-dienes and isothiocyanates to furnish functionalized 2-thiohydantoins which are transformed into thiohydantoin-fused tetrahydropyrazines by subsequent regioselective base-promoted cyclization.
![Graphical abstract: Access to novel imidazo[1,5-a]pyrazine scaffolds by the combined use of a three-component reaction and a base-assisted intramolecular cyclization](http://scimg.chem960.com/usr/1/C4OB00676C.jpg)
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Journal Name：Organic & Biomolecular Chemistry
research_products
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CAS no.: 89640-58-4
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