Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement?

Organic & Biomolecular Chemistry Pub Date: 2017-01-24 DOI: 10.1039/C7OB00129K

Abstract

Acquiring a divergent response from homologous protein domains is essential for selective ligand–protein interactions. Stereospecific fluorination of (?)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.

Graphical abstract: Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement
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