Direct C–H amination and C–H chloroamination of 7-deazapurines?
RSC Advances Pub Date: 2014-11-12 DOI: 10.1039/C4RA13143F
Abstract
Protocols for selective Pd–Cu-catalyzed direct C–H amination or C–H chloroamination of 7-deazapurines with N-chloro-N-alkyl-arylsulfonamides have been developed leading either to 8-(arylsulfonyl)methylamino-7-deazapurines or to 7-chloro-8-(arylsulfonyl)methylamino-7-deazapurines. The scope and limitations of the methods, as well as synthesis of a small series of 6,8,9-tri- and 6,7,8,9-tetrasubstituted 7-deazapurines and deprotection of the sulfonamide are presented.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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